Our world is rapidly evolving, especially for children, youth and families living in fragile and humanitarian settings. Thriving among uncertainty and tumult depends on a level of preparedness, access to information and proactive scanning of the horizon to identify and address emerging challenges to mental health and well-being. By forging strategic partnerships among humanitarian, data science, practitioner, business, and technology sectors, we pioneer innovative approaches to anticipatory action planning and identification of resilience practices to safeguard mental health and wellbeing amidst the complexities of ever-changing global landscape. While most are focused on humanitarian response, we additionally employ a forward-thinking strategy to prevent and mitigate risks that threaten child and family mental health and wellbeing.